Sacubitril Hemicalcium

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    库 比 曲 半 钙盐 Sacubitril Hemicalcium 1369773-39-6 Ninu Ile
    库 比 曲 钠盐 149690-05-1 Ninu Ile
    LCZ-4 1426129-50-1 Ninu Ile
    LCZ-7 1012341-48-8 Ninu Ile
    LCZ-8 1012341-50-2 Ninu Ile
    LCZ-9 149690-12-0 Ninu Ile

 

Lẹhin

AHU-377 iyọ kemikali jẹ fọọmu iyọ iyọmi ti AHU-377. O jẹ onidena ti neprilysin pẹlu iye IC50 ti 5 nM [1].

AHU-377 ati angiotensin II AT1 olugba atako antagonist valsartan ṣajọ LCZ696 ni ipin molar 1: 1. LCZ696 jẹ onigbọwọ olugba neprilysin olugba angiotensin. O le dinku titẹ ẹjẹ ati pe o le jẹ oogun aramada fun itọju ikuna ọkan. AHU-377 jẹ oogun-pro, o le yipada nipasẹ pipin enzymatic ti ethyl ester sinu fọọmu ti nṣiṣe lọwọ LBQ657. O royin pe AHU-377 (30 ati 100 iwon miligiramu / kg, PO) le fa ipa antihypertensive ni ọna igbẹkẹle iwọn lilo ni awọn eku DAHI-SS. Ṣugbọn ninu awọn eku hypertensive DOCA-iyọ, o ṣe afihan idinku ailera [2, 3].

Awọn itọkasi:
[1] Ksander GM, Ghai RD, deJesus R, Diefenbacher CG, Yuan A, Berry C, Sakane Y, Trapani A. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 Oṣu Karun 12; 38 (10): 1689-700.
[2] Voors AA, Dorhout B, van der Meer P. Ipa ti o le jẹ ti valsartan + AHU377 (LCZ696) ninu itọju ikuna ọkan. Iwé Opin Investig Drugs. 2013 Oṣu Kẹjọ; 22 (8): 1041-7.
[3] Laxminarayan G Hegde, Cecile Yu, Cheruvu Madhavi et al. Iṣe afiwera ti AHU-377, oludena neprilysin ti o lagbara, ni awọn awoṣe eku meji ti haipatensonu igbẹkẹle iwọn didun. BMC Pharmacology 2011, 11 (Ipese 1): P33.

Ilana kemikali

Sacubitril Hemicalcium

Iwe-ẹri

2018 GMP-2
原料药GMP证书201811(captopril ,thalidomide etc)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-Letter-201901

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