China Bictegravir 1611493-60-7 tita ati awọn olupese |CPF

Bictegravir 1611493-60-7

Apejuwe kukuru:

Orukọ API	Itọkasi	Innovator	Ọjọ Itọsi Itọsi (AMẸRIKA)
Bictegravir 1611493-60-7	HIV-1 ikolu	Awọn sáyẹnsì Gileadi	Oṣu kejila ọjọ 19, Ọdun 2033

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Bictegravir jẹ aramada, oludena agbara ti HIV-1 ṣepọ pẹlu IC50 ti 7.5 nM.

Ninu Vitro

Bictegravir (BIC) ṣe idiwọ iṣẹ gbigbe okun pẹlu IC50 ti 7.5± 0.3 nM.Ni ibatan si idinamọ rẹ ti iṣẹ gbigbe okun, Bictegravir jẹ inhibitor alailagbara pupọ ti 3"-iṣẹ ṣiṣe ti HIV-1 IN, pẹlu IC50 ti 241±51 nM.Bictegravir ṣe alekun ikojọpọ ti awọn iyika 2-LTR ~ 5-agbo ibatan si iṣakoso ẹlẹgàn ati dinku iye awọn ọja isọpọ otitọ ni awọn sẹẹli ti o ni arun nipasẹ 100-agbo.Bictegravir ni agbara lati ṣe idiwọ ẹda HIV-1 ni mejeeji MT-2 ati awọn sẹẹli MT-4 pẹlu EC50s ti 1.5 ati 2.4 nM, lẹsẹsẹ.Bictegravir ṣe afihan awọn ipa antiviral ti o lagbara ni mejeeji CD4+ T lymphocytes akọkọ ati awọn macrophages ti ari monocyte, pẹlu EC50s ti 1.5±0,3 nM ati 6,6±4.1 nM, lẹsẹsẹ, eyiti o jẹ afiwera si awọn iye ti a gba ni awọn laini T-cell[1].

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