Apejuwe

Calcium Pitavastatin (NK-104 hemicalcium) jẹ oludena reductase hydroxymethylglutaryl-CoA (HMG-CoA) ti o lagbara.Calcium Pitavastatin (NK-104 hemicalcium) ṣe idiwọ iṣelọpọ idaabobo awọ lati acetic acid pẹlu IC50 ti 5.8 nM ninu awọn sẹẹli HepG2.Calcium Pitavastatin jẹ idamẹrin olugba lipoprotein-cholesterol (LDL-C) hepatocyte to munadoko.Anti-akàn aṣayan iṣẹ-ṣiṣe.

abẹlẹ

Calcium Pitavastatin jẹ oludena ifigagbaga ti henensiamu HMGCR (HMG-CoA reductase) awọn abajade ni idinku ninu iṣelọpọ idaabobo awọ LDL.Awọn ijinlẹ miiran fihan pe pitavastatin le dinku iṣelọpọ atẹgun ninu awọn sẹẹli endothelial nipasẹ didi NADPH oxidase.Ni afikun, pitavastatin dinku ikosile ti eNOS mRNA lakoko ti o pọ si idahun ti o gbẹkẹle NO ti o mu nipasẹ acetylcholine ati kalisiomu ionophore, A23187.Pẹlupẹlu, pitavastatin ṣe idiwọ ilana-soke ti awọn ikanni potasiomu ti ṣiṣẹ kalisiomu nipasẹ idinku awọn ipele idaabobo awọ ninu awọn sẹẹli.

Ibi ipamọ

4°C, aabo lati ina

* Ninu epo: -80°C, oṣu mẹfa;-20°C, oṣu kan (dabobo lati ina)

Ilana kemikali

Jẹmọ Biological Data