Captopril
Apejuwe
Captopril (SQ-14534) jẹ apaniyan ti o lagbara, ifigagbaga ti enzymu iyipada angiotensin (ACE).
Ninu Vitro
Captopril (SQ-14534) ti han lati ni iru aisan ati awọn anfani iku si awọn ti diuretics ati beta-blockers ni awọn alaisan haipatensonu.Captopril (SQ-14534) ti ṣe afihan lati ṣe idaduro ilọsiwaju ti nephropathy dayabetik, ati enalapril ati lisinopril ṣe idiwọ idagbasoke nephropathy ni awọn alaisan normoalbuminuric pẹlu àtọgbẹ[1].Ipin equimolar ti cis ati awọn ipinlẹ trans ti Captopril (SQ-14534) wa ninu ojutu ati pe henensiamu yan ipo kabo ti inhibitor nikan ti o ṣafihan imudara ayaworan ati stereoelectronic pẹlu isobusitireti abuda groove[2].
MCE ko tii jẹrisi deede awọn ọna wọnyi.Wọn wa fun itọkasi nikan.
Iwadii isẹgun
| Nọmba NCT | Onigbowo | Ipo | Ọjọ Ibẹrẹ | Ipele |
| NCT03179163 | Ile-ẹkọ giga Ipinle Penn | Okan Orilẹ-ede, Ẹdọfóró, ati Ile-ẹkọ Ẹjẹ (NHLBI) | Haipatensonu, Pataki | Oṣu Keje 20, Ọdun 2016 | Ipele 1 |Ibala 2 |
| NCT03660293 | Ile-ẹkọ giga Tanta | Àtọgbẹ mellitus, oriṣi 1 | Oṣu Kẹrin Ọjọ 1, Ọdun 2017 | Ko ṣiṣẹ fun |
| NCT03147092 | Centro Neurológico de Pesquisa ati Reabiitação, Brazil | Haipatensonu |Iwọn Ẹjẹ | Oṣu Kẹta Ọjọ 1, Ọdun 2018 | Ipele Ibẹrẹ 1 |
| NCT00252317 | Rigshospitalet, Denmark | Aortic Stenosis | Oṣu kọkanla ọdun 2005 | Ipele 4 |
| NCT02217852 | West China Hospital | Haipatensonu | Oṣu Kẹjọ Ọdun 2014 | Ipele 4 |
| NCT01626469 | Brigham ati Ile-iwosan Awọn Obirin | Iru 2 Àtọgbẹ mellitus | Oṣu Karun ọdun 2012 | Ipele 1 |Ibala 2 |
| NCT00391846 | AstraZeneca | Ikuna ọkan | Oṣu Kẹwa Ọdun 2006 | Ipele 4 |
| NCT00240656 | Hebei Medical University | Haipatensonu, Ẹdọforo | Oṣu Kẹwa Ọdun 2005 | Ipele 1 |
| NCT00086723 | Ile-ẹkọ giga Ariwa iwọ-oorun | Ile-ẹkọ Akàn ti Orilẹ-ede (NCI) | Tumor Agba to lagbara ti ko ni pato, Ilana kan pato | Oṣu Keje Ọdun 2003 | Ipele 1 |Ibala 2 |
| NCT00663949 | Shiraz University of Medical Sciences | Nephropathy dayabetik | Oṣu Kẹta ọdun 2006 | Ipele 2 |Ibala 3 |
| NCT01437371 | Ile-iwosan Yunifasiti, Clermont-Ferrand|Oṣiṣẹ|LivaNova | Ikuna Okan | Oṣu Kẹjọ Ọdun 2011 | Ipele 3 |
| NCT04288700 | Ile-ẹkọ giga Ain Shams | Hemangioma ọmọ ikoko | Oṣu Kẹjọ Ọjọ 1, Ọdun 2019 | Ipele 4 |
| NCT00223717 | Ile-ẹkọ giga Vanderbilt | Ile-iṣẹ iṣoogun ti Ile-ẹkọ giga Vanderbilt | Haipatensonu | Oṣu Kẹta ọdun 2001 | Ipele 1 |
| NCT02770378 | Yunifasiti ti Ulm | Awọn itọju ailera akàn ti o gbẹkẹle | Fund Anticancer, Belgium | Glioblastoma | Oṣu kọkanla ọdun 2016 | Ipele 1 |Ibala 2 |
| NCT01761916 | Instituto Materno Infantil Ojogbon Fernando Figueira | Preeclampsia | Oṣu Kẹta ọdun 2013 | Ipele 4 |
| NCT01545479 | Instituto de Cardiologia do Rio Grande do Sul | Arun Renal | Oṣu Kẹta ọdun 2010 | Ipele 4 |
| NCT00935805 | Hospital de Clinicas de Porto Alegre|Conselho Nacional de Desenvolvimento Científico e Tecnológico|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil | Àtọgbẹ mellitus|Haipatensonu iṣan | Oṣu Keje Ọdun 2006 |
|
| NCT00742040 | Ile-iwosan fun Awọn ọmọde Arun | Arun okan | Oṣu Kẹjọ Ọdun 2008 | Ipele 2 |
| NCT03613506 | Ile-ẹkọ giga Wuhan | Ipa ipa Radiotherapy|Gbigba Captopril | Oṣu Kẹjọ Ọjọ 25, Ọdun 2018 | Ipele 2 |
| NCT00004230 | Ile-ẹkọ giga Ariwa iwọ-oorun | Ile-ẹkọ Akàn ti Orilẹ-ede (NCI) | Akàn | Oṣu Kẹwa Ọdun 1999 | Ipele 3 |
| NCT00660309 | Novartis | Iru 2 Àtọgbẹ mellitus | Oṣu Kẹrin Ọjọ 2008 | Ipele 4 |
| NCT00292162 | NHS Greater Glasgow ati Clyde | Ikuna Okan Onibaje|Atrial Fibrillation | Oṣu Kẹta ọdun 2007 | Ko ṣiṣẹ fun |
| NCT01271478 | Coordinación de Investigación en Salud, Mexico | Ìgbóná|Àrùn kídirin ìpele ìparí | Oṣu Kẹjọ Ọdun 2009 | Ipele 4 |
| NCT04193137 | Chongqing Medical University | Aldosteronism akọkọ | Oṣu kọkanla ọjọ 30, ọdun 2019 |
|
| NCT00155064 | Ile-iwosan Ile-ẹkọ giga ti Orilẹ-ede Taiwan | Hyperaldosteronism | Oṣu Keje Ọdun 2002 | Ipele 4 |
| NCT01292694 | Ile-ẹkọ giga Vanderbilt | Ile-iṣẹ iṣoogun ti Ile-ẹkọ giga Vanderbilt | Haipatensonu|Ìkùnà Àdánù Àdánù Mímọ́|Atrophy Ètò Ọ̀pọ̀ | Oṣu Kẹta ọdun 2011 | Ipele 1 |
| NCT00917345 | Ile-iwosan Ile-ẹkọ giga ti Orilẹ-ede Taiwan | Novartis | Aldosteronism akọkọ | Oṣu Kẹta ọdun 2008 |
|
| NCT00077064 | Ìtọjú Ìtọjú Oncology Group|National Cancer Institute (NCI)|NRG Oncology | Akàn Ẹdọfóró|Àwọn Ìparí Ẹ̀dọ̀fóró|Fibrosis Ìtọ́jú | Oṣu Kẹfa ọdun 2003 | Ipele 2 |
Ibi ipamọ
| Lulú | -20°C | 3 odun |
| 4°C | ọdun meji 2 | |
| Ni epo | -80°C | osu 6 |
| -20°C | osu 1 |
Ilana kemikali
Igbero18Awọn iṣẹ akanṣe Igbelewọn Iṣeduro Didara eyiti o ti fọwọsi4, ati6ise agbese ni o wa labẹ alakosile.
Eto iṣakoso didara agbaye ti ilọsiwaju ti fi ipilẹ to lagbara fun tita.
Abojuto didara n ṣiṣẹ nipasẹ gbogbo igbesi aye ọja lati rii daju didara ati ipa itọju ailera.
Ẹgbẹ Aṣoju Iṣeduro Ọjọgbọn ṣe atilẹyin awọn ibeere didara lakoko ohun elo ati iforukọsilẹ.
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