Remdesivir

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Orukọ API Itọkasi Innovator Ọjọ Itọsi Itọsi (AMẸRIKA)
Remdesivir Awọn ọlọjẹ (Ebola, Covid-19) Gileadi  

 


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Remdesivir jẹ oogun apakokoro ti o fojusi ọpọlọpọ awọn ọlọjẹ. O ti ni idagbasoke ni akọkọ ni ọdun mẹwa sẹhin lati tọju jedojedo C ati ọlọjẹ ti o dabi tutu ti a pe ni ọlọjẹ syncytial atẹgun (RSV). Remdesivir kii ṣe itọju to munadoko fun boya arun naa. Ṣugbọn o ṣe afihan ileri lodi si awọn ọlọjẹ miiran.

Awọn oniwadi ṣe idanwo remdesivir ni awọn idanwo ile-iwosan lakoko ibesile Ebola. Awọn oogun iwadii miiran ṣiṣẹ daradara, ṣugbọn o han pe o jẹ ailewu fun awọn alaisan. Awọn ẹkọ-ẹkọ ninu awọn sẹẹli ati awọn ẹranko daba pe atunṣe jẹ doko lodi si awọn ọlọjẹ ninu idile coronavirus, gẹgẹbi Arun Arun atẹgun ti Aarin Ila-oorun (MERS) ati Arun Inu atẹgun nla (SARS).

Remdesivir ṣiṣẹ nipa didaduro iṣelọpọ ti ọlọjẹ naa. Coronaviruses ni awọn jiini ti o jẹ ribonucleic acid (RNA). Remdesivir ṣe idiwọ pẹlu ọkan ninu awọn enzymu bọtini ti ọlọjẹ nilo lati tun RNA ṣe. Eleyi idilọwọ awọn kokoro lati isodipupo.

Awọn oniwadi bẹrẹ idanwo aileto kan, idanwo iṣakoso ti antiviral ni Kínní 2020 lati ṣe idanwo boya atunṣe le ṣee lo lati tọju SARS-CoV-2, coronavirus ti o fa COVID-19. Ni Oṣu Kẹrin,tete esitọka pe remdesivir ṣe imularada isare fun awọn alaisan ile-iwosan pẹlu COVID-19 ti o lagbara. O di oogun akọkọ lati gba aṣẹ lilo pajawiri lati Ile-iṣẹ Ounje ati Oògùn AMẸRIKA (FDA) lati tọju awọn eniyan ti o wa ni ile-iwosan pẹlu COVID-19.

Awọn oniwadi ti pari idanwo naa, ti a mọ si Idanwo Itọju COVID-19 Adaptive (ACTT-1). Iwadi na ni owo nipasẹ National Institute of Allergy and Infectious Diseases (NIAID). Ik Iroyin han ninu awọnNew England Akosile ti IsegunOṣu Kẹjọ Ọjọ 8, Ọdun 2020.

Ijẹrisi

2018 GMP-2
原料药GMP证书201811 (captopril, thalidomide ati bẹbẹ lọ)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-lẹta-201901

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