Chlorothiazide

Apejuwe kukuru:

Orukọ API Itọkasi Sipesifikesonu US DMF EU DMF CEP
Chlorothiazide Diuretics USP/EP      


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Apejuwe ọja

abẹlẹ

Chlorothiazide jẹ inhibitor ti carbonic anhydrase ati pe o kere diẹ si agbara ju acetazolamide. A ti ṣe afihan agbo-ara yii lati dènà isọdọtun ti iṣuu soda ati awọn ions kiloraidi.

Apejuwe

Chlorothiazide jẹ diuretic ati antihypertensive. (IC50=3.8 mM) Ifojusi: Awọn omiiran Chlorothiazide sodium (Diuril) jẹ diuretic ti a lo laarin eto ile-iwosan tabi fun lilo ti ara ẹni lati ṣakoso omi pupọ ti o ni nkan ṣe pẹlu ikuna ọkan iṣọn-alọ ọkan. O tun lo bi antihypertensive. Nigbagbogbo a mu ni fọọmu egbogi, a maa n mu ni ẹnu lẹẹkan tabi lẹmeji ni ọjọ kan. Ni eto ICU, chlorothiazide ni a fun lati diurese alaisan ni afikun si furosemide (Lasix). Ṣiṣẹ ni ọna ti o yatọ ju furosemide lọ, ti o wọ inu inu bi idadoro ti a ṣe atunṣe ti a nṣakoso nipasẹ tube nasogastric tube (NG tube), awọn oogun meji n mu ara wọn lagbara.

Iwadii isẹgun

Nọmba NCT Onigbowo Ipo Ọjọ Ibẹrẹ

Ipele

NCT03574857 Yunifasiti ti Virginia Ikuna Ọkan Oṣu Kẹfa ọdun 2018

Ipele 4

NCT02546583 Ile-ẹkọ giga Yale | Okan ti Orilẹ-ede, Ẹdọfóró, ati Ile-ẹkọ Ẹjẹ (NHLBI) Ikuna Okan Oṣu Kẹjọ Ọdun 2015

Ko ṣiṣẹ fun

NCT02606253 Ile-ẹkọ giga Vanderbilt | Ile-iṣẹ iṣoogun ti Ile-ẹkọ giga Vanderbilt Ikuna Okan Oṣu Kẹta ọdun 2016

Ipele 4

NCT00004360 Ile-iṣẹ Orilẹ-ede fun Awọn orisun Iwadi (NCRR) | Ile-ẹkọ giga Ariwa iwọ-oorun | Ọfiisi ti Awọn Arun Rare (ORD) Àtọgbẹ Insipidus, Nephrogenic Oṣu Kẹsan 1995

NCT00000484 Okan ti Orilẹ-ede, Ẹdọfóró, ati Ile-ẹkọ Ẹjẹ (NHLBI) Àwọn Àrùn Ẹ̀dọ̀ Ẹ̀jẹ̀|Àwọn àrùn ọkàn Oṣu Kẹrin ọdun 1966

Ipele 3

Ilana kemikali

Chlorothiazide

Ijẹrisi

2018 GMP-2
原料药GMP证书201811 (captopril, thalidomide ati bẹbẹ lọ)
GMP-of-PMDA-in-Chanyoo-平成28年08月03日 Nantong-Chanyoo-Pharmatech-Co
FDA-EIR-lẹta-201901

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