Bictegravir 1611493-60-7
Apejuwe
Bictegravir jẹ aramada, oludena agbara ti HIV-1 ṣepọ pẹlu IC50 ti 7.5 nM.
Ninu Vitro
Bictegravir (BIC) ṣe idiwọ iṣẹ gbigbe okun pẹlu IC50 ti 7.5± 0.3 nM. Ni ibatan si idinamọ rẹ ti iṣẹ gbigbe okun, Bictegravir jẹ inhibitor alailagbara pupọ ti 3"-iṣẹ ṣiṣe ti HIV-1 IN, pẹlu IC50 ti 241±51 nM. Bictegravir ṣe alekun ikojọpọ ti awọn iyika 2-LTR ~ 5-agbo ibatan si iṣakoso ẹlẹgàn ati dinku iye awọn ọja isọpọ otitọ ni awọn sẹẹli ti o ni arun nipasẹ 100-agbo. Bictegravir ni agbara lati ṣe idiwọ ẹda HIV-1 ni mejeeji MT-2 ati awọn sẹẹli MT-4 pẹlu EC50s ti 1.5 ati 2.4 nM, lẹsẹsẹ. Bictegravir ṣe afihan awọn ipa antiviral ti o lagbara ni CD4+ T lymphocytes akọkọ ati awọn macrophages ti o ni monocyte, pẹlu EC50s ti 1.5±0,3 nM ati 6,6±4.1 nM, lẹsẹsẹ, eyiti o jẹ afiwera si awọn iye ti a gba ni awọn laini T-cell[1].
MCE ko tii jẹrisi deede awọn ọna wọnyi. Wọn wa fun itọkasi nikan.
| Nọmba NCT | Onigbowo | Ipo | Ọjọ Ibẹrẹ | Ipele |
| NCT03998176 | Ile-ẹkọ giga ti Nebraska | Awọn sáyẹnsì Gilead | HIV-1-ikolu | Oṣu Kẹjọ Ọjọ 9, Ọdun 2019 | Ipele 4 |
| NCT03789968 | Ile-ẹkọ giga Thomas Jefferson | Ile-ẹkọ giga ti Maryland, Ile-ẹkọ giga College | Ilera Ile-ẹkọ giga Indiana | Ile-iṣẹ Ile-iwosan Brooklyn | Ile-ẹkọ giga ti Illinois ni Chicago | Ile-ẹkọ giga Guusu Guusu Nova | Ile-ẹkọ giga ti California, San Francisco | HIV+AIDS | Oṣu Kẹsan Ọjọ 1, Ọdun 2019 | |
| NCT04249037 | Yunifasiti ti Colorado, Denver | Awọn sáyẹnsì Gilead | HIV+AIDS | Oṣu Kẹta Ọjọ 1, Ọdun 2020 | Ko ṣiṣẹ fun |
| NCT04132674 | Ile-iṣẹ Arun Arun ti Vancouver | Iwoye Immunodeficiency Eniyan Ikolu | Lilo Oogun | Oṣu kọkanla ọjọ 26, ọdun 2018 | Ipele 4 |
| NCT04054089 | Cristina Mussini | Yunifasiti ti Modena ati Reggio Emilia | Awọn akoran HIV | Oṣu Kẹsan 2019 | Ipele 4 |
| NCT04155554 | Azienda Ospedaliera Universitaria Senese|Catholic University of the Sacred Heart|Ospedale Policlinico San Martino|Azienda Ospedaliera San Paolo|Ospedale Amedeo di Savoia | HIV-1-ikolu | Oṣu Kẹta Ọjọ 29, Ọdun 2020 | Ipele 3 |
| NCT02275065 | Awọn sáyẹnsì Gileadi | HIV-1 Ikolu | Oṣu Kẹwa Ọdun 2014 | Ipele 1 |
| NCT03711253 | University of Southern California | Ikolu HIV nla | Oṣu Kẹwa Ọjọ 14, Ọdun 2019 | Ipele 4 |
| NCT02400307 | Awọn sáyẹnsì Gileadi | HIV | Oṣu Kẹrin Ọjọ 17, Ọdun 2015 | Ipele 1 |
| NCT03499483 | Fenway Community Health | Idena HIV | Oṣu Kẹta Ọjọ 24, Ọdun 2019 | Ipele 4 |
| NCT03502005 | Ẹgbẹ Iwadi Midland, Inc. | Awọn sáyẹnsì Gilead | Kokoro ajesara eniyan | Oṣu Kẹta Ọjọ 1, Ọdun 2018 | Ipele 4 |
Ilana kemikali
Igbero18Awọn iṣẹ akanṣe Igbelewọn Iṣeduro Didara eyiti o ti fọwọsi4, ati6ise agbese ni o wa labẹ alakosile.
Eto iṣakoso didara agbaye ti ilọsiwaju ti fi ipilẹ to lagbara fun tita.
Abojuto didara n ṣiṣẹ nipasẹ gbogbo igbesi aye ọja lati rii daju didara ati ipa itọju ailera.
Ẹgbẹ Aṣoju Iṣeduro Ọjọgbọn ṣe atilẹyin awọn ibeere didara lakoko ohun elo ati iforukọsilẹ.
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