Vericiguat
Vericiguat jẹ apyrazolopyridineiyẹn ni5-fluoro-1H-pyrazolo [3,4-b] pyridineninu eyiti amino hydrogen ni ipo 1 ti rọpo nipasẹ ẹgbẹ 2-fluorobenzyl ati awọnhydrogenni ipo 3 ti rọpo nipasẹ 4,6-diamino-5-[(methoxycarbonyl) amino] pyrimidin-2-yl ẹgbẹ. O ti wa ni a tiotukaguanylatecyclase stimulator eyiti a lo fun itọju ikuna ọkan onibaje. O ni o ni a ipa bi a tiotukaguanylateactivator cyclase, oluranlowo vasodilator ati oluranlowo antihypertensive. O jẹ ẹyaaminopyrimidine, apyrazolopyridine, ester carbamate ati agbo organofluorine kan.
Vericiguat wa labẹ iwadii ni iwadii ile-iwosan NCT02861534 (Iwadii ti Vericiguat ni Awọn olukopa Pẹlu Ikuna Ọkàn Pẹlu Idinku Idinku Idinku (HFrEF) (MK-1242-001)).
Vericiguat jẹ SolubleGuanylateStimulator Cyclase. Ilana iṣe ti vericiguat jẹ bi aGuanylateStimulator Cyclase.
Vericiguat jẹ oogun ti a lo lati ṣakoso ati ṣe itọju ikuna ọkan pẹlu ida ida ejection ti o dinku (HFrEF). O wulo fun ikuna ọkan ti o buru si onibaje, ikuna ọkan ti o bajẹ laipẹ. Vericiguat ko pẹ iwalaaye ṣugbọn ṣe idilọwọ isọdọtun ile-iwosan. Iṣẹ ṣiṣe ṣe ilana awọn itọkasi, ilana iṣe, iwọn lilo, ati ipo iṣakoso nipasẹ ẹgbẹ alamọdaju, awọn ipa buburu, awọn ilodisi, ati awọn idanwo pupọ lati ṣe atilẹyin ẹri iwulo oogun naa ni HFrEF.
Igbero18Awọn iṣẹ akanṣe Igbelewọn Iṣeduro Didara eyiti o ti fọwọsi4, ati6ise agbese ni o wa labẹ alakosile.
Eto iṣakoso didara agbaye ti ilọsiwaju ti fi ipilẹ to lagbara fun tita.
Abojuto didara n ṣiṣẹ nipasẹ gbogbo igbesi aye ọja lati rii daju didara ati ipa itọju ailera.
Ẹgbẹ Aṣoju Iṣeduro Ọjọgbọn ṣe atilẹyin awọn ibeere didara lakoko ohun elo ati iforukọsilẹ.
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