Apejuwe

Hydrochlorothiazide (HCTZ), oogun diuretic ti nṣiṣe lọwọ ẹnu ti kilasi thiazide, ṣe idiwọ iyipada TGF-β/ Smad ifihan ipa ọna. Hydrochlorothiazide ni awọn ipa isinmi ti iṣan taara nipasẹ ṣiṣi ti kalisiomu-mu ṣiṣẹ potasiomu (KCA). Hydrochlorothiazide ṣe ilọsiwaju iṣẹ ọkan ọkan, dinku fibrosis ati ni ipa antihypertensive.

abẹlẹ

Hydrochlorothiazide jẹ oogun diuretic ti kilasi thiazide.

Ninu Vitro

Hydrochlorothiazide jẹ ti kilasi thiazide ti diuretics. O dinku iwọn didun ẹjẹ nipasẹ ṣiṣe lori awọn kidinrin lati dinku isọdọtun iṣuu soda (Na) ninu tubule convoluted distal. Aaye pataki ti iṣe ni nephron yoo han lori eleto-irin-ajo Na + -Cl nipasẹ idije fun aaye kiloraidi lori gbigbe. Nipa ibajẹ gbigbe Na ni tubule convoluted jijin, hydrochlorothiazide nfa natriuresis kan ati pipadanu omi concomitant. Thiazides ṣe alekun isọdọtun ti kalisiomu ni apakan yii ni ọna ti ko ni ibatan si gbigbe iṣuu soda. Ni afikun, nipasẹ awọn ọna ṣiṣe miiran, Hydrochlorothiazide ni a gbagbọ lati dinku resistance iṣan agbeegbe.

Hydrochlorothiazide (HCTZ; ẹnu bygavage; 12.5 mg/kg/d; 8 ọsẹ) ti mu iṣẹ ọkan ọkan dara si, fibrosis interstitial ọkan ti o dinku ati ida iwọn didun collagen, idinku ikosile ti AT1, TGF-β ati Smad2 ninu awọn iṣan ọkan ọkan ninu awọn eku Sprague Dawley agba agbalagba. Ni afikun, hydrochlorothiazide dinku pilasima angiotensin II ati awọn ipele aldosterone. Pẹlupẹlu, hydrochlorothiazide ṣe idiwọ angiotensin II ti o fa TGF-β1 ati Smad2 ikosile amuaradagba ninu awọn fibroblasts ventricular eku ọmọ tuntun.

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