Daclatasvir Dihydrochloride
Apejuwe
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) jẹ alagbara ati lọwọ ẹnu.HCV NS5A amuaradagbaonidalẹkun pẹluEC50s ibiti o ti 9-146 pM funọpọ HCV ẹda genotypes. Daclatasvir dihydrochloride jẹ tun kanOrganic anion gbigbe polypeptide 1B (OATP1B)atiOATP1B3onidalẹkun pẹluIC50s ti 1.5 µM ati 3.27 µM, lẹsẹsẹ.
IC50& Àkọlé
EC50: 50 pM (HCV replicon genotype 1a), 9 pM (HCV replicon genotype 1b), 71 pM (HCV replicon genotype 2a), 146 pM (HCV replicon genotype 3a), 12 pM (HCV replicon genotype 4a) ati HCV ẹda genotype 5a)[1]
Kd: 8 nM (NS5A33-202) ati 210 nM (NS5A26-202)[2]
IC50: 1.5 µM (OATP1B) ati 3.27 µM (OATP1B3)[3]
Ninu Vitro
Daclatasvir (BMS-790052) ṣe afihan iṣẹ ṣiṣe inhibitory ti o lagbara si gbogbo awọn idanwo genotypes, pẹlu EC50iye orisirisi lati 9 pM to 146 pM. Daclatasvir ṣe idiwọ HCV ẹda genotype 1a, 1b, 2a, 3a, 4a ati 5a pẹlu EC50awọn iye ti 50 pM, 9 pM, 71 pM, 146 pM, 12 pM ati 33 pM, lẹsẹsẹ. Daclatasvir jẹ oludaniloju to lagbara ti JFH-1 genotype 2a kokoro àkóràn ti o ṣe atunṣe ni aṣa sẹẹli (EC).50= 28pm)[1]. Daclatasvir (BMS-790052) sopọ mọ NS5A33-202 ati NS5A26-202 pẹlu Kds ti 8 nM ati 210 nM, lẹsẹsẹ[2].
Ibi ipamọ
| Lulú | -20°C | 3 odun |
| 4°C | ọdun meji 2 | |
| Ni epo | -80°C | osu 6 |
| -20°C | osu 1 |
Iwadii isẹgun
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Igbero18Awọn iṣẹ akanṣe Igbelewọn Iṣeduro Didara eyiti o ti fọwọsi4, ati6ise agbese ni o wa labẹ alakosile.
Eto iṣakoso didara agbaye ti ilọsiwaju ti fi ipilẹ to lagbara fun tita.
Abojuto didara n ṣiṣẹ nipasẹ gbogbo igbesi aye ọja lati rii daju didara ati ipa itọju ailera.
Ẹgbẹ Aṣoju Iṣeduro Ọjọgbọn ṣe atilẹyin awọn ibeere didara lakoko ohun elo ati iforukọsilẹ.
Korea Countec Bottled Laini apoti
Taiwan CVC Laini Iṣakojọpọ Igo
Italy CAM Board Packaging Line
German Fette Compacting Machine
Japan Viswill Tablet Oluwari
DCS Iṣakoso yara
International ifowosowopo
Abele ifowosowopo
Kọ ifiranṣẹ rẹ nibi ki o si fi si wa
