abẹlẹ

Calcium Atorvastatin jẹ oludena agbara ti HMG-CoA reductase pẹlu iye IC50 ti 150 nM.
HMG-CoA reductase jẹ enzymu bọtini ti ọna mevalonate eyiti o ṣe agbejade idaabobo awọ.HMG-CoA jẹ henensiamu aropin-oṣuwọn ati pe o ṣe pataki fun idinku awọn ipele idaabobo awọ ẹjẹ.HMG-CoA reductase wa ninu reticulum endoplasmic ati pe o ni awọn ibugbe transmembrane mẹjọ ninu.Awọn oludena ti HMG-CoA reductase le fa ikosile LDL (lipoprotein iwuwo kekere) awọn olugba ninu ẹdọ.O yori si alekun awọn ipele catabolism ti pilasima LDL ati dinku ifọkansi ti idaabobo awọ pilasima eyiti o jẹ ipinnu pataki ti atherosclerosis.HMG-CoA reductase ṣe ipa pataki ninu iṣelọpọ idaabobo awọ.HMG-CoA jẹ ibi-afẹde kan fun awọn oogun ti o dinku idaabobo awọ.HMG-CoA reductase tun jẹ enzymu pataki fun idagbasoke.Iṣẹ ṣiṣe ti HMG-CoA reductase ni ibatan si awọn abawọn iṣilọ sẹẹli germ.Idilọwọ iṣẹ ṣiṣe rẹ le ja si iṣọn-ẹjẹ inu cerebral [1].
Atorvastatin jẹ inhibitor HMG-CoA reductase pẹlu iye IC50 ti 154 nM.O munadoko ninu itọju awọn dyslipidemia kan ati hypercholesterolemia[1].Itọju Atorvastatin ni 40 miligiramu dinku idaabobo awọ lapapọ ti 40% lẹhin awọn ọjọ 40.A tun lo lati tọju awọn alaisan iṣọn-ẹjẹ tabi ọpọlọ pẹlu awọn ipele idaabobo awọ deede.[2]Atorvastatin tun dinku apheresis lipoprotein iwuwo kekere ninu awọn alaisan nipasẹ jijẹ ikosile awọn olugba LDL.
O jẹ metabolized si awọn metabolites pupọ eyiti o ṣe pataki fun ipa awọn iṣe itọju ailera nipasẹ CYP3A4 (cytochrome P450 3A4).[3]
Awọn itọkasi:
[1].van Dam M, Zwart M, de Beer F, Smelt AH, Prins MH, Trip MD, Havekes LM, Lansberg PJ, Kastelein JJ: Lilo igba pipẹ ati ailewu ti atorvastatin ni itọju iru III ti o nira ati apapọ dyslipidemia.Ọkàn 2002, 88 (3): 234-238.
[2].Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT et al: Idena ti iṣọn-alọ ọkan ati awọn iṣẹlẹ ikọlu pẹlu atorvastatin ni awọn alaisan haipatensonu ti o ni apapọ tabi isalẹ ju. Awọn ifọkansi idaabobo awọ aropin, ninu Idanwo Awọn abajade ọkan ọkan Anglo-Scandinavian--Lipid Lowering Arm (ASCOT-LLA): idanwo iṣakoso aileto ti ọpọlọpọ aarin.Lancet 2003, 361 (9364): 1149-1158.
[3].Lennernas H: awọn oogun elegbogi ti atorvastatin.Clin Pharmacokinet 2003, 42 (13): 1141-1160.

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